Modular Polymeric Nanoshells for Precision AntiviralAnticancer Vaccination
Innovations Modular Polymeric Nanoshells for Precision AntiviralAnticancer Vaccination
  • Technology Introduction
Effectively inducing cytotoxic T cell expansion has been a critical challenge in vaccine development. To address this challenge, an entirely biodegradable polymeric nanoshell was invented to couple antigens and adjuvants for safe and potent immune potentiation. The invention has been adopted for precision anticancer vaccine, broadly reactive influenza vaccine, and an effective vaccine MERS-CoV.
 
  • Scientific Innovation
The biodegradable polymeric nanoshell fundamentally addresses the critical challenge in nano-encapsulation of water soluble and combinatorial compounds. The T cell stimulating capacity stemming from the nanoshell-based vaccines is unparalleled by any viral vector or non viral vector-based vaccine platforms. The platform is highly versatile for developing novel antiviral and anticancer nanoformulations.
 
  • This technology won the Futuretech Breakthrough Award in 2019 Future Tech Expo.
 
  • Institutes
Academia Sinica
Che-Ming Jack Hu /chu@ibms.sinica.edu.tw



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