Innovations Human pluripotent stem cell therapy for ischemic heart disease
■Technology Introduction
  1. We used a cardiac differentiation protocol to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CM).
  2. We used catheter-based infarct surgery to create large myocardial infarction in macaque.
  3. Via thoracotomy, we intramuscularly injected hPSC-CMs into infarcted hearts to remuscularize the infarcted heart and provide durable improvement in cardiac function.
■Scientific Innovation
Using a catheter-based infarct surgery, we successfully established a large myocardial infarction model in monkeys. Then we performed thoracotomy to intramuscularly inject 1 billion cryopreserved hPSC-CMs into infarcted hearts. Our data demonstrate that remuscularization of the infarcted macaque heart with human myocardium provides durable improvement in left ventricular function.
■This technology won the Futuretech Breakthrough Award in 2018 Future Tech Expo. 

National Cheng Kung University
Yi-Hsein Fang/