Low-intensity pulsed ultrasound (LIPUS) has been shown to induce neuroprotective effects against brain injury and cognitive dysfunction in rats by increasing BDNF protein levels in the brain. We demonstrated that LIPUS treatment significantly prevented memory impairment and cognitive dysfunction by transcranial ultrasound stimulation.
 

This technology provides the possibility that manipulation of BDNF by transcranial ultrasound stimulation (TUS) might provide a new therapeutic strategy for treating dementia. Thus, the generation of endogenous BDNF via LIPUS stimulation may represent a novel noninvasive technique for treating patients with diseases of the CNS.
 

National Yang-MIng University
Wei-Shen Su/fyyang@ym.edu.tw